The summer intern will be working with talented and highly experienced biostatisticians. The intern will have the opportunity to work closely with project teams and develop knowledge about the therapeutic area, clinical trial and real-world study designs, key endpoints and analysis strategies.
The intern’s summer project will focus on how best to quantify treatment benefits offered by products in Sarepta’s portfolio on important efficacy measures in clinical trials as well as real world settings. Different statistical evaluation techniques will be compared not only on statistical properties but also on clinical interpretability and suitability with the company’s regulatory and commercial strategy. The goal will be to identify a scientifically sound method that maximizes the probability of regulatory success and fits commercial needs. The intern will build upon the work done last summer on understanding the evaluation of treatment effect in delaying the significant DMD progression milestone of loss of ambulation (LOA). Further research will be conducted on how best to analyze LOA to demonstrate treatment effect and how to perform personalized predictions given key patient characteristics and functional outcomes at landmark times. It is expected that the work will lead to internal recommendations and scientific communications that have far-ranging impact for the DMD community. It will also provide opportunities for the intern to showcase their abilities and hone new skills.
Primary Responsibilities Include:
- The intern will be responsible for developing understanding of the company’s data on key efficacy measurements, perform analysis of repeated measures data and time to event data.
- The intern will perform statistical simulations in SAS and/or R to assess different statistical methods/models and their performance.
- Perform ad-hoc and exploratory statistical analyses as needed.
- Support and contribute to the preparation of publications, including manuscripts, posters, and oral presentations.
Desired Education and Skills:
- MS or equivalent in statistics, biostatistics or related field, preferably a PhD candidate
- Proficiency in statistical methods, including generalized linear mixed models, survival analysis.
- Ability to handle large data in SAS and R and perform statistical simulations
- Knowledge and hands-on experience with causal inference, survival analysis, propensity score methods, external control comparison, Bayesian methods desirable
- Excellent communication and presentation skills, including the ability to effectively communicate statistical and data science concepts in a clear and concise manner to non-technical audience.
- Good organizational skills, sufficient to multi-task in a fast-paced environment with changing priorities.
- Team player, with ability to collaborate successfully across functions.
- Candidates must be legally allowed and available to work full-time for up to 12 weeks in the summer of 2024
Program Timeline:
- This application is for a 10 or 12-week summer internship program that will either start on May 28th or June 10th.
- The program will conclude on August 16th, 2024.
This is a remote position where in-office presence is not required.
This position is remote. However, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $21 – $25 per hour depending upon years of education completed and nature of role.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.