Scripps Research is ranked the most influential institution in the world for its impact on innovation. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Together, we cultivate new scientific leaders and expand the frontiers of knowledge to deliver medical breakthroughs to better human health around the globe. If you have a passion for making a difference, this could be your opportunity to join our transformative team.
POSITION TITLE: Research Assistant II
The Davis Lab in the Department of Neuroscience at the Scripps Research Institute (http://www.scripps.edu/davis) is seeking to hire a Research Assistant II to help develop new therapeutics for the treatment of neurodegenerative diseases. The lab has a large effort that focuses on the impairments in mitochondria in neurons that occur in Alzheimer’s disease, ALS, and other neurodegenerative diseases. We employ multiple techniques in this pursuit, including cell-based assay development; high content screening of small molecules; cell culture of mouse neurons, human neurons derived from iPSCs, and other immortalized cell types; molecular biology and in vivo testing of drugs in both Drosophila and mouse models for neurodegenerative diseases.
The successful candidate may help with the vivo testing of drugs in animal models for diseases, which will include taking measures of mitochondrial dynamics and function; performing molecular biological techniques to probe mitochondrial dynamics and function that include Western blotting, Seahorse assays, ATP generation assays, and mitochondrial isolation; and/or behavioral assays of animal models for the diseases such as locomotor activity, measurements of neuromuscular control and strength, and learning and memory. Alternatively, the successful candidate may participate in the ongoing analysis of potential therapeutics that the lab has identified, including conducting cell-based assays for mitochondrial dynamics and/or function using primary neurons from the mouse and/or iPSC-derived neurons. The assays include high-content assays in 384 or 1536 well microtiter plates.
RESPONSIBILITIES AND DUTIES
- Work under minimal supervision. Independently conducts a wide variety of standard laboratory techniques/procedures while using judgement when necessary to adapt standard methods and techniques. Receive instructions on specific assignment objectives, complex features, and possible solutions.
- Provide interpretation and analyses of results. Troubleshoot and modify procedures.
- May assist in designing experiments to complete a segment of overall research plan. May provide routine equipment maintenance. May provide guidance/training to department personnel.
- Details of established essential functions for this position will be addressed/discussed during the interview process.
- Requires a bachelor’s degree in a relevant scientific discipline or an equivalent combination of education, training and/or experience from which comparable knowledge, skill and abilities have been attained.
- Requires 3-5 years of experience.
- Candidates possessing a master’s degree, 2+ years’ experience required.
- Excellent organizational, presentation and collaboration skills.
- Ability to work independently, troubleshoot experiments and meet deadlines. A self-starter.
- Keep accurate records and follow protocol instructions.
- Experience with mouse/rat husbandry, brain dissection, and/or molecular biological assays.
- Experience with cell culture techniques and high content or similar assays in microtiter dishes.
- Florida and Palm Beach County residents preferred.
Commensurate with experience
The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
The safety and well-being of our candidates, our people and their families continues to be a top priority. Until restrictions change, interviews will be conducted virtually.