We are seeking a highly motivated postdoctoral fellow for a joint appointment in the laboratories of Weiru Wang in Structural Biology Department and Avi Ashkenazi in Cancer Immunology Department at Genentech. The postdoc will apply X-ray crystallography and/or cryo-EM in combination with biochemical and other biophysical methods to explore the mechanistic basis of regulation in the unfolded protein response pathway. The successful applicants will have solid background in structural biology and biochemistry with hands on experience in protein purification, biochemical experimentation and protein crystallography. A strong interest in understanding of protein structure and function is highly desired. We have access to state-of-the-art mass spectrometry, crystallography and cryo-EM facilities. The postdoc will have opportunity to drive basic research in a collaborative setting, and the work is expected to result in significant advances and publications in top tier journals.
- Recent or pending PhD and strong experience in structural biology, biochemistry, biophysics or related fields.
- Hands-on experience with laboratory techniques in related disciplines.
- Experience in computational modeling is a plus.
- Demonstrated track record of successful innovative research as evidenced by one or more first author publication in leading peer-reviewed journals.
- Excellent oral and written communication skills, ability to collaborate within multidisciplinary environment, and a high degree of intellectual independence.
Relevant Lab Publications:
- Ferri E et al. (2020) Activation of the IRE1 RNase Through Remodeling of the 1 Kinase Front Pocket by ATP-competitive ligands, Nature Comm, 11(1):6387
- Harnoss JM et al. (2020) IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment, Cancer Res, 80(11):2368
- Harnoss JM et al. (2019) Disruption of IRE1α through its kinase domain attenuates multiple myeloma, PNAS, 116 (33):16420
- Chang T et al. (2018) Coordination between two key branches of the unfolded protein response determines apoptotic cell fate. Mol Cell 79, 629(4).
- Lu M et al. (2014) Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 2014 345(6192), 98.
- Beveridge R et al. (2020) Structure-Based Design Evolution of Amino-Quinazoline BRaf Kinase Ligands as IRE1a Inhibitors: Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1a Inhibitory Activity, ACS Med Chem Lett, https://doi.org/10.1021/acsmedchemlett.0c00344
More information about the Genentech Postdoctoral Program:
More information about the labs of Weiru Wang and Avi Ashkenazi: