We have an exciting opportunity for a highly motivated postdoctoral fellow to join the Department of Early Discovery Biochemistry at Genentech. The postdoctoral candidate will investigate protein – protein interactions and develop peptide probes for modulating targets of therapeutic interest by utilizing biochemical, biophysical and structural biology approaches. The group utilizes a multidisciplinary molecular approach for peptide discovery and target validation, encompassing diversity methods such as phage display. Projects will focus on molecular understanding of new targets and protein complexes that are important in cancer and stem cell biology and dissecting their biochemical mechanisms of regulation. The individual will work independently in a team-oriented environment and collaborate with experts in oncology and immunology to apply the pharmacological strategies to study cellular signaling pathways. Proficiency in X-ray crystallography and/or cryo-EM methods is strongly preferred.
Candidates must have a Ph.D. in biochemistry, biophysics, structural biology or related discipline and a proven record of productivity in their graduate career as demonstrated by first-author publications.
Additional Recommended Qualifications:
- Strong experience in molecular biology
- Expertise in engineering, expressing and purifying challenging proteins
- Proficient in structural biology and / or cryo-EM
- Experience with directed evolution (yeast, phage, mRNA display, etc.) is preferred
- Experience with tissue culture, cell-based assays is a plus.
- Strong analytical, collaborative, communication and organizational skills
More information about the Genentech Postdoctoral Program:
More information about the Hannoush lab:
A Nile, F de Sousa E Melo, S Mukund, R Piskol, S Hansen, L Zhou, Y Zhang, Y Fu, E Gogol, L Kömüves, Z Modrusan, S Angers, Y Franke, C Koth, W Fairbrother, W Wang, F de Sauvage, RN Hannoush. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature Chemical Biology 2018, 14, 582-590.
A Nile, S Mukund, K Stanger W Wang and RN Hannoush. Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt binding. PNAS 2017, 114, 4147-4152.
X Gao, K Stanger, H Kaluarachchi H, T Maurer, P Ciepla, C Chalouni, Y Franke, RN Hannoush. Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking. Sci Rep. 2016, 6:35179.
X. Gao, RN Hannoush, Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine. Nature Chemical Biology 2014, 10, 61-68.