Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
A highly motivated post-doctoral research fellow is sought to carry out a research project in the lab of Dr. A. McGarry Houghton at Fred Hutchinson Cancer Research Center in Seattle, WA.
About the Lab
Lung cancer is the leading cause of cancer deaths worldwide, accounting for ~160,000 lives each year in the US alone. The Houghton Lab’s current research program focus is to comprehensively study the host immune response to non-small cell lung cancer (NSCLC). The lab also studies the role of myeloid lineage cells within the lung tumor microenvironment. Studies in this area are centered upon the mechanisms by which neutrophil lineage cells antagonize lymphocyte functions within the tumor microenvironment.
The Post-Doctoral Fellow will contribute to the Lab’s research agenda with a focus on the identification of tumor microenvironmental factors that dictate success or failure to immune checkpoint blockade. This project will involve single cell sequencing experiments and subsequent data analysis. The project will also involve the use of novel mouse models of lung cancer that rely on cigarette smoke exposure in mice to generate lung adenocarcinomas with a high mutational spectral burden. The fellow will conduct independent and collaborative research resulting in presentations and publications.
The techniques involved will include working with mouse models of lung cancer (Kras/p53, Pten/Lkb1, LLC syngeneic models, etc.) both with and without cigarette smoke exposure and carefully studying the immune response to the tumor using flow cytometry, multiplexed-immunohistochemistry, gene expression analyses (qPCR), protein assessment (ELISA) and others. Experience with single cell sequencing, RNAseq, and whole exome sequencing is preferred. Manipulation of these model systems with immune-based and other oncology drugs are commonplace in the lab. These in vivo studies will be supplemented by in vitro studies involving multicellular culture system, assays of cellular chemotaxis, function and viability and other standard protocols. The ability to analyze the complex datasets resulting from the above experimentation is essential.
To be considered, candidates must have:
- A recent PhD, MD/PhD, or MD in a relevant biological field
- Candidate is expected to have project leadership experience in a team environment, and must be able to work independently with little supervision.
- Excellent written and verbal communications skills are essential.
Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at firstname.lastname@example.org or by calling 206-667-4700.