Why join us?
FogPharma® is pioneering the discovery, development, and commercialization of HeliconTM peptides, an exciting new drug modality that uniquely combines the cell-permeability of traditional small molecule drugs with the specificity, broad target accessibility and discovery speed of monoclonal antibody drugs. Our patented Helicon peptide technology allows us to modulate the activity of well-known intracellular disease drivers that have thus far evaded small molecule and biologic therapies.
FogPharma’s lead program targets β-Catenin, a cancer driver in the WNT pathway. Inhibition of β-Catenin has the potential to benefit more than one-fifth of all cancer patients, and is just one of many opportunities for Fog’s lead-discovery platform to change future medicines, therapies and lives. We recently selected a lead development candidate and plan to initiate clinical development early next year.
What’s the opportunity?
FogPharma is working on a ground-breaking, new modality that is transforming the future of medicines. Join a high-performing, interdisciplinary team of scientists who are discovering novel inhibitors of undruggable disease targets! Your role would be to build and produce high diversity phage libraries and screen them against undruggable protein targets using our high-throughput platform, and perform next generation sequencing (NGS). You will also collaborate with our multidisciplinary scientists, who are successfully employing our powerful Helix Discovery Engine, to study and understand the novel peptide inhibitors. Ideal candidates will be energetic and passionate, with a broad range of molecular biology expertise, including phage display and next generation sequencing, and have an interest in working in a dynamic, fast-paced environment.
- Perform DNA library cloning using standard molecular biology tools
- Amplify and purify phage libraries (M13 phage and phagemid systems)
- Utilize standard molecular biology techniques, such as electroporation, plaque assay, bacterial culture, PCR
- Perform high-throughput screening and NGS
- Document experimental plans and laboratory procedures in a timely manner and with attention to detail
- Utilize laboratory automation when needed
What you’ll need to be successful:
- B.S. or M.S. in biology, biochemistry, or a related field with a minimum of 1 year of research experience. Industry experience is preferred.
- Experience in DNA cloning and library production is highly desirable.
- Hands-on experience with molecular biology and biochemistry techniques, such as PCR, cloning, bacterial culture, or biochemical assays.
- Experience with NGS protocols and laboratory automation is a plus
- Experience with display screening methods, such as phage display, yeast display, or mRNA display is preferred.
- Excellent organization and time management skills.
- Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)
As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
30 Acorn Park Drive | Cambridge, MA 02140 | www.fogpharma.com