We are seeking a highly motivated and innovative Co-op to support the development of off-the-shelf, allogeneic human iPSC (induced Pluripotent Stem Cell)-based T cell therapies. The individual will have the opportunity to work closely with a passionate group of scientists to develop and evaluate immune cell cloaking strategies in order to increase the persistence of our allogeneic T cell product, a key barrier to off-the-shelf cell therapies. The person will perform iPSC/immune cell culture, immune cell assay development, and genetic knock-in/knock-out studies to evaluate various methods to cloak our cell product against immune rejection. The student will be exposed to the entire spectrum of the discovery process in a drug development setting, from early target validation to analysis of samples from in-vivo studies. The student will learn how to design well-controlled experiments, analyze complex data sets, and is expected to present findings in research team meetings. This position is ideal for a candidate who is entrepreneurial and eager to develop skills in molecular biology and immunology within a drug development setting, working toward the realization of off-the-shelf T cell therapies to save patients’ lives.
- Culture, engineer and maintain human iPSCs and Immune Cells
- Design and construction of genetic constructs for target validation
- Development of immune cell assays to characterize various cloaking engineering approaches, such as ELISA, ELISPOT, flow cytometry, qPCR, and cellular cytotoxicity
- Collaborate with colleagues to advance our internal programs
- Analyze and present experimental data to our internal team and collaborators.
- Be a good lab citizen by sharing in lab responsibilities to maintain a well-functioning lab
- Maintain an electronic lab notebook and contribute to support documentation
- Mammalian cell culture experience
- Basic molecular biology techniques
- Working knowledge of various software (e.g., MS office, GraphPad Prism, FlowJo)
- Passionate, self-motivated, and determined to do great science.
- Highly organized and scientifically rigorous with significant attention to detail.
- Demonstrated ability to work and think independently.
- A desire to make a difference
- Patients First – Proactively and constructively engage to deliver results for those in need. “Begin with patient’s success in mind”
- Communication and Respect – Foster open exchange with colleagues and collaborators. Seek to understand and treat people with courtesy. “Better together”
- Integrity & Excellence – Act honestly and ethically to seek the truth. Courageously doing the right thing – take smart risks and make tough decisions in pursuit of exceptional outcomes. “Get it done right”