Biogen is a pioneering leader in developing therapeutics against challenging neurological disorders. Our team has a unique opportunity to leverage new understanding of human microglial biology, genetics, and cutting-edge technologies allowing discovery of transformative medicines for patients with diseases in which microglial pathology contribute to its diagnosis and progression.
The Research Organization at Biogen is seeking a highly motivated scientist to join our highly collaborative, multi-disciplinary cross-Research initiative focused on the discovery of novel therapeutics for diseases with microglial pathology. The Research Fellow/Scientist I role at Biogen is an 18-month position designed to provide a unique opportunity for academically-trained scientists to gain exposure to drug development and train in an industry research setting.
The individual is expected to lead, design, and execute an independent research project aimed at the development of a humanized chimeric microglial rodent model and leverage it for drug discovery programs across multiple therapeutic areas (AD, PD, MS, and other neurodegenerative diseases). The work will be expected to support new target identification, active drug discovery programs, and advance our understanding of human microglia biology. The Research Fellow is expected to work independently and collaboratively in a cross-functional environment, drawing on deep and current knowledge of literature. The work will involve a wide array of in vitro, in vivo, and analytical techniques using cellular and molecular approaches, and is expected to advance projects towards clinical development.
- Develop creative and innovative research plans to address key questions in microglial pathology in disease
- Design and conduct in vitro and in vivo experiments and analytics in collaboration with team members
- Prepare, review and deliver scientific presentations for internal and external use
- Build strong collaborations across the Research organization at Biogen and become a key member of a cross-research unit initiative focused on microglia biology
- Keep abreast of state-of-the-art technologies in the field
- Write reports, manuscripts and generate data packages supporting model development and drug candidate advancement
- PhD in Neuroscience or related field, and 0-2 years of postdoctoral experience in academic or industry settings.
- Excellent technical skills, a successful track record proven by peer-reviewed publications in neurobiology using current technologies, excellent communication and collaboration skills, and strong understanding of variety of technologies applied to biological and genetic research in Neuroscience
- Strong self-motivation and drive to make impactful contributions
- Experience differentiating and analyzing iPSC lines using quality control assays such as flow cytometry and immunocytochemistry
- A strong background in microglial biology and iPSC technology
- Experience handling mice
- Experience working with in vivo models including human cell xenograft models using immunodeficient mice, surgical models, and genetically engineered models
- In vivo technical skills including dosing, aseptic techniques, tissue collection and immunohistochemistry
- Postdoc experience is preferred but not required